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This translocation triggers inflammatory cytokine expression and immune activation (38, 39)

Images were captured using a biological microscope (BA210T, Motic), and quantitative analysis was performed using the ImageJ software (NIH)

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They were randomized to receive either PIO (in a daily dose of 15 mg) or placebo for 24 weeks, followed by a 24-week PIO extension for those who had completed the main study

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