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Sci Rep UK 6(1):18 Joshi A, Newbatt Y, McAndrew PC, Stubbs M, Burke R, Richards MW et al (2015) Molecular mechanisms of human IRE1 activation through dimerization and ligand binding

Endoplasmic reticulum stress ER stress occurs when protein folding capacity is overwhelmed, leading to activation of the unfolded protein response (UPR) [124]

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In another embodiment the otic formulation or composition comprises a microsphere formulation or composition wherein the sterility of the microsphere is ensured by sterile filtration of the precursor organic solution and aqueous solutions

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