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According to FDA and European Medicines Agency (EMA) guidelines for DDI trials [39, 40], the systemic exposure of the perpetrator drug (oral semaglutide) should generally be the exposure obtained with the highest recommended dose under therapeutic (steady state) conditions

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Many women are overweight or obese at diagnosis, and we know that excess body fat predicts worse outcomes: higher recurrence rates, increased breast cancerspecific mortality, and higher overall mortality