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The nuclear translocation of activated AKT induced the phosphorylation of FoxO proteins which evoked the 14-3-3-mediated export of FoxO proteins from the nuclei
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However, full-length TB-4 is biologically fragile, expensive to synthesize, and has poor shelf stability, making it less practical for research or commercial use
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The protein expression and activation of FAK and paxillin were determined by Western blot analysis, and the phosphorylation levels of both FAK and paxillin were dose-dependently increased by BPC-157, while the total amounts of protein were unaltered