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Although a single RCT failed to observe a statistically significant improvement in HOMA-IR (85), this discrepancy is more likely attributable to limited sample sizes, restricted follow-up windows, and heterogeneity in baseline metabolic phenotypes rather than a lack of efficacy

A 2016 study reports that l-arginine may help reduce high blood pressure in adults with hypertension

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Lippincott Williams & Wilkins

Rotate injection sites to prevent lipohypertrophy, which is the buildup of fatty tissue from repeated injections in the same location

This practice, known as stacking, creates a synergistic effect