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General oxidative stress models: Across multiple experimental models of kidney injury (ischemia-reperfusion, toxin exposure, aging), higher tissue glutathione consistently correlates with less renal damage, and depletion consistently correlates with more

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doi: 10.1001/jama.295.9.1011 73 KimSMKimSYParkCSChangHSParkKC

Thus, these molecules reinforce antioxidant defense both transcriptionally and metabolically, closing the feedback loop between IR, OS, and cellular dysfunction in PCOS

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