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Factors that may trigger perioral dermatitis include the following: Drugs: steroid creams, ointments, and inhalers Fluorinated toothpaste Skincare lotions and creams, especially those containing petroleum jelly, paraffin base, and isopropyl myristate Sunscreens Makeup products Certain scented skincare products Ultraviolet (UV) light Heat Dust Wind Certain infections Oral contraceptives Hormones Vitamin B12 deficiency What are the signs of perioral dermatitis

This activates intracellular signaling cascades: PKA (Protein Kinase A) and PKC (Protein Kinase C) pathways

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Enzymatic Cofactor Activity : Serves as an essential cofactor for glutathione peroxidase and glutathione reductase enzymes, enabling these protective systems to neutralize hydrogen peroxide and lipid peroxides that would otherwise damage cellular membranes

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