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GLP-1 medications can significantly delay gastric emptying

The trial was small and short, and the participants were predominantly already taking metformin (some with a sulfonylurea) alongside diet and exercise, which makes it hard to isolate the probiotic's specific contribution

The FDA has raised concerns about the increased risk of dosing errors, improper storage and fraudulently labeled GLP-1s from compounding pharmacies

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Similarly, the SURMOUNT-4 trial showed substantial weight regain following tirzepatide discontinuation