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Research has identified that doses exceeding 0.75g/kg body weight (approximately 51g for a 150-pound individual) may elevate blood ammonia levels, potentially causing toxicity symptoms

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Although cancer cells typically show a metabolic shift toward increased glycolysis and reduced oxidative phosphorylation, a metabolic adaptation known as the Warburg effect, they still depend on mitochondrial ATP production for survival (Weinberg and Chandel, 2015