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Meanwhile, the outer membrane will rupture, and proteins, such as cytochrome c and apoptosis-inducing factor (AIF), will be released from the intermembrane space into the cytosol, triggering apoptosis [190, 191]

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Common adverse events included nausea (33.9%) and were largely attributable to the surgical setting rather than the drug itself

Japanese Ministry of Health, Labour and Welfare

Mechanistically, BPC-157 appears to function through nitric oxide-mediated vasodilation, angiogenic factor regulation, and recruitment of fibroblasts and endothelial progenitor cells 1-3

Moreover, Mendelian randomization analyses support a causal role for specific gut microbes: Actinobacteria and Bifidobacterium taxa appear protective, while Lactobacillaceae increase anxiety risk (Lai and Xiong, 2025)