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The vein swells and changes color, resulting in the formation of varicose veins

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The activity of the antioxidant enzyme, superoxide dismutase 2 (SOD2) is upregulated by melatonin through the promotion of the activity of sirtuin 3 ( SIRT3 ) which deacetylates SOD2, thus activating it 82,83

For best results, use it twice daily, morning and night, followed by a moisturizer.

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