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Gastrointestinal (GI) issues

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Moreover, in mice with colitis, administration of CLA (c9, t11, and t10, c12 isomers in a 50/50 ratio) at doses greater than 10 mg/day resulted in reduced inflammation and oxidative stress [46]

Environmental enrichment prevents stress-induced epigenetic changes in the expression of glucocorticoid receptor and corticotrophin releasing hormone in the central nucleus of the amygdala to inhibit visceral hypersensitivity