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doi: 10.3389/fgstr.2026.1802268 Received 02 February 2026 Revised 24 March 2026 Accepted 24 March 2026 Published 10 April 2026 Volume 5 - 2026 Edited by Ramars Amancy, Indian Institute of Chemical Technology (CSIR), India Reviewed by Faizan Ahmed, Cincinnati Childrens Hospital Medical Center, United States Zoofa Zayani, Nicolaus Copernicus University in Toru, Poland Updates Copyright 2026 Chooklin and Chuklin

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[1] Renal manifestations Mild polyuria Macroscopic hematuria Flank and/or abdominal pain Recurrent UTIs Nephrolithiasis Signs of CKD (e.g., fluid overload, uremia) Palpable, enlarged kidneys (usually normal at birth) Extrarenal manifestations Digestive Hepatic cysts: multiple, benign, mostly asymptomatic, and more prevalent with age Pancreatic cysts Colonic diverticulosis Abdominal or inguinal hernias Cardiovascular Symptoms of hypertension

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