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By the 1980s, it was touted as a weight-loss remedy and muscle-building substance

For the remaining 8%, the diagnosis was probable and included four cases of partial carnitine palmitoyl transferase deficiency, three cases of malignant hyperthermia, and two rare inherited disorders

The latter, in turn, promotes ovarian theca cell steroidogenesis and suppresses hepatic synthesis of sex hormone-binding globulin (SHBG), thus increasing free testosterone levels and driving HA (72)

[26] showed that liraglutide-dependent weight loss relies on its binding to GLP-1Rs located mainly in POMC/CART (cocaine- and amphetamine-regulated transcript) anorexigenic neurons in the ARC, but an indirect inhibitory effect of agouti-related peptide (AgRP) orexigenic neurons via -aminobutyric acid (GABA)-ergic signaling was also observed

While leg cramps are not typically listed as a primary side effect in clinical trials, they are a frequent topic of conversation among those using GLP-1 medications

doi: 10.1152/japplphysiol.00599.2016