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These local reactions typically resolve quickly and diminish with continued use as technique improves

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This inhibitory action contributes to glycines calming and reflex-modulating effects on the spinal cord-for example, helping regulate motor-neuron activity and muscle tone

Screening may be warranted in patients with one or more risk factors, such as gastric or small intestine resections, inflammatory bowel disease, use of metformin for more than four months, use of proton pump inhibitors or histamine H 2 blockers for more than 12 months, vegans or strict vegetarians, and adults older than 75 years