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The gut microbiome-derived metabolite trimethylamine N-oxide modulates neuroinflammation and cognitive function with aging

It implies that ER is required for execution of this RCD [164]

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It works the same way mechanistically, activating the GLP-1 receptor to reduce appetite, slow gastric emptying and improve insulin sensitivity, but the small molecule structure means it can be taken orally with fewer absorption constraints. In trials, orforglipron lowered blood sugar and produced meaningful weight loss in people with obesity and in those with type 2 diabetes, says LaValle

doi: 10.1016/j.cmet.2018.04.010 140