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Use during pregnancy and lactation should be limited to cases where the benefits outweigh the risks, as high-dose parenteral administration has not been fully studied in these populations

Drug Interactions 7.1 Impact of Other Drugs on Amlodipine CYP3A Inhibitors Coadministration with CYP3A inhibitors (moderate and strong) results in increased systemic exposure to amlodipine and may require dose reduction

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Frequently Reported Effects Headache and nausea are among the most frequently reported adverse reactions in regulated afamelanotide studies

10.3389/fphar.2020.600421 Front

Understanding what you are looking at makes accurate dosing much easier