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Vitamin B12 plays a direct role in maintaining myelin, the protective coating around nerve fibers

Timing of administration relative to surgical procedures, optimal dosing in perioperative settings, and integration with standard post-operative care protocols require clinical investigation before establishing evidence-based perioperative protocols

Each node represents an amino acid residue color-coded by chemical property

The reconstitution math is identical regardless of compound

J Pharmacol Sci 2007

Several NAD+ precursor molecules were released to replace NAD+, demonstrating that NAD+ replacement is what generates the beneficial effects (25)