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Food Chem 120:12011209 [Google Scholar] Kashanian S, Dolatabadi JEN (2009) DNA binding studies of 2-tert-butylhydroquinone (TBHQ) food additive

10.3389/fendo.2022.924299 75 ShiY.GuoZ.LiuF.PanS.GaoD.ZhouS.et al (2023a)

They may recommend that you re-titrate, which means dropping back down to a lower dose for a few weeks to let your body get used to the medication again

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This does not automatically invalidate them, but it means they have not undergone the rigor that clinical trials for pharmaceutical GLP-1 compounds must pass