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Since then, several in vitro and in vivo studies about the effect of SFN have been conducted, including clinical trials, resulting in relevant information regarding prevention and treatment of diseases such as pancreatic cancer [17], breast cancer [18], diffuse axonal injury [19], lymphomas [20], liver cancer [21], leukemia [22], and prostate cancer [23]

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Pickart isolated the responsible factor and identified it as a small peptide with the sequence glycyl-L-histidyl-L-lysine