These models provide complementary insights into the pathophysiology of AD, highlighting the distinct temporal and biochemical dynamics of amyloid pathology and cognitive decline
The FDA requires extensive animal testing before human trials specifically because dangerous substances generally produce detectable harm in animal models
After 23 relapses, around 58 days p.i., mice developed an early chronic progressive disease course characterized by stable paresis or paralysis from which they did not recover anymore
doi: 10.1016/j.jtemb.2017.06.008
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