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The study was powered to assess non-inferiority and, if this was achieved, superiority of orforglipron 36 mg versus semaglutide 14 mg and of orforglipron 12 mg versus semaglutide 7 mg

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CH-NPs have become one of the most promising delivery systems for cancer chemotherapy and diagnosis because of the unique characteristics they possess, i.e., decomposition, remarkable cell-membrane penetration, high drug-carrying capacity, pH-dependent therapeutic releasing, versatility, and extended residence duration within the blood-stream (Figure 7

Increased Intestinal Fluid and Electrolyte Secretion Another reason semaglutide can cause watery diarrhea is its effect on intestinal secretions

GLP-1 agonists like semaglutide and tirzepatide slow gastric emptying by 30-40% as part of their mechanism of action (Nauck et al., Diabetologia, 2011)