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Causal mediation analysis showed both direct and indirect effects of tirzepatide on UACR

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Shared genetic risk factors Beyond shared environmental risk factors, such as poor diet, sedentary lifestyle, and disturbed sleep, which may also be direct manifestations of psychopathology, shared genetic components have been identified between MDD and T2DM [54]

Improved range of motion at injury sites

Systemically delivered amitriptyline produced even more durable effects, maintaining synaptic integrity in treated animals for up to 1 year post-treatment (Fernandez et al., 2021), underscoring the translational potential of TrkB-based strategies for auditory synaptopathy, a key pathological substrate of tinnitus