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The anti-diabetic efficacy of diverse polyphenols has been demonstrated in both in vivo and in vitro studies, supporting their potential as therapeutic agents (388, 389)

Most of these side effects are not serious, but they can be uncomfortable

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It is primarily manifested by increased intracellular iron levels and enhanced lipid peroxidation, ultimately leading to cell death characterized by mitochondrial shrinkage, loss of cristae, and disruption of membrane integrity ( The Gut Microbiota, as a vital component of the intestinal microenvironment, plays a pivotal role in maintaining intestinal homeostasis, modulating host immune responses, participating in metabolic regulation, and promoting nutrient absorption

However, severe vomiting, abdominal pain, dehydration, persistent constipation, or vision changes need medical attention

Pharmacologic studies that look at constipation define it as less than three bowel movements per week, along with the presence of at least one of the above symptoms in more than 25 percent of bowel movements