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MRI revealed symmetrical white matter lesions in the corticospinal tract (Wolters et al., 1982), while diffusion tensor imaging highlighted impaired white matter connectivity due to myelin damage rather than axonal injury (Bora et al., 2012)

By interfering with this hyperactivated process, P140 reduces the presentation of self-antigens to T cells, effectively dampening the autoimmune drive at one of its key control points

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