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10.1016/j.ccr.2021.214402 269 RuanQ.YuanL.GaoS.JiX.ShaoW.MaJ.et al (2023)

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Mechanism of increase in plasma intact GLP-1 by metformin in type 2 diabetes: stimulation of GLP-1 secretion or reduction in plasma DPP-4 activity

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Semaglutide (the active ingredient) has no direct pharmacological interactions with estrogen or progestin found in hormonal contraceptives, making concurrent use medically safe