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The clinical success of dual and triple incretin agonists has validated the concept that engaging multiple complementary pathways within a single molecular framework can yield superior efficacy without proportionally increasing toxicity (Finan et al., 2016)

The most well-known, so-called skinny shots are semaglutide and tirzepatide

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Sepesi B, Schmidt HE, Lada M, Correa A, Walsh GL, Mehran RJ, Rice DC, Roth JA, Vaporciyan AA, Ajani JA, Watson TJ, Swisher SG , Low DE, Hofstetter WL

They examined data on 17,604 people who were at least 45 years old who were either overweight or obese