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Structures of the GLP-1R in complex with G s , bound with GLP-1 and exendin-P5, as well as non-peptide ligands, have been determined using cryo-EM 13,16,27

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Similarly, 4-aminobiphenyl, metabolized by hepatic CYP1A2, produces reactive intermediates that form DNA adducts in hepatocytes, increasing the mutational burden [27]