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Dropout was higher in the 12 mg arm than in the 9 mg arm, reinforcing a pattern already visible in Phase 2: the marginal efficacy gain from pushing to 12 mg comes at real tolerability cost

The safety profile of oral semaglutide is similar to injectables, with the most common adverse events being gastrointestinal side effects like nausea, diarrhea, and constipation

Only 8% of the total cohort were low early responders, and of those, just 23% eventually reached 15% total weight loss

62 RGT075 RGT075 is a small oral GLP-1RA identified through Computer-Accelerated Rational Design (CARD) with potent G-protein-coupled cAMP signaling

Hydroxytyrosol (HT) is a compound that can be extracted from olive fruit which is considered to be one of the most potent antioxidants to be researched for its benefits on weight loss, due to its antidiabetic mechanisms relating to an increase in insulin signalling