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Mtb can also incorporate propionyl-CoA into its cell wall, including the virulence-associated lipids phthiocerol dimycocerosates (PDIM) and the trehalose ester family (sulfolipid-1 (SL-1), diacyltrehalose, triacyltrehalose, and polyacyltrehalose), which are synthesised from malonyl-CoA (produced from acetyl CoA) and methylmalonyl-CoA (produced from propionyl-CoA) (Lee et al, 2013)

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b , The alternation of surface mainly derived from an outstanding conformational change of the loop between Pro124 and Ala133, with which the side chains of Arg152 formed multiple hydrogen bonds in the wild-type, but not His152 in the mutant