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Efficacy endpoints for semaglutide compared to placebo, stratified by obesity class at baseline, were assessed using both the full analysis set (all randomized participants according to the intention-to-treat principle, regardless of treatment discontinuation) and the on-treatment data (including only patients receiving allocated study medication)

Thankfully, false-positive pregnancy tests are rare, but they can happen

Depending on findings, further investigations may be warranted

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Until such studies are conducted, the combination remains investigational and should be approached with appropriate caution, written informed consent, and consideration of FDA MedWatch reporting for any adverse events that occur with off-label combination use

Two-way ANOVA with repeated measures and post-hoc Tukeys multiple comparisons correction was performed on analyses with three genotypes and housing temperature over time