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Clinical findings 5 indicate that peptides in the same family as PDA can downregulate pro-inflammatory cytokines such as TNF- and IL-6, while boosting anti-inflammatory signaling

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In imiquimod-induced lupus mice, the prebiotic Hirsutella sinensis polysaccharides and the probiotic Parabacteroides goldsteinii significantly reduced disease markers, including spleen weight, proteinuria, anti-dsDNA autoantibodies, and STAT signaling levels, while improving renal and hepatic function parameters