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It is known that the Angiotensin IV/AT4 system: has cerebroprotective effects, augments long term potentiation, has well established pro-cognitive effects, and is suspected to regulate neural stem cell development

Neuropharmacology 223:109293 Liu Y et al (2025) Dapagliflozin alleviated seizures and cognition impairment in pilocarpine induced status epilepticus via suppressing microglia-mediated neuroinflammation and oxidative stress

For data that did not follow a normal distribution, non-parametric tests were applied

For athletes, its also important to note that AOD9604 is currently prohibited by the World AntiDoping Agency (WADA), meaning competitive sports users could risk antidoping violations

Other PTMs of NRF2 In addition to the above-mentioned PTMs, NRF2 undergoes a variety of other PTMs that also play important roles in regulating its stability, activity, and cellular localization

McDonald, P.R