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Side Effects Gastrointestinal symptoms: Most common adverse effects were mild-to-moderate nausea, vomiting, and diarrhea, occurring primarily during dose escalation [6] [12]
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Such maladaptive neural plasticity could lead to abnormal patterns of autonomic and neuroendocrine acitivity.35,36 The fact that vomiting and retching during the emetic phase of CVS are mainly produced when the stomach is empty, implies that the allostatic feedback mechanisms are disordered, which could give rise to a reduced threshold for vomiting and retching, regardless of physiologic necessity or peripheral information
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