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1) Patients with hypersensitivity reaction to thioctic acid (a-lipoic acid) and components of this drug 2) Children and adolescents (less clinical experience) 3

Conventional treatments relying on antibiotics and synthetic antioxidants raise concerns over residue accumulation, microbial resistance, and tissue toxicity 7,8,9

FIGURE 8 Statements Data availability statement TThe data presented in the study are deposited in the NCBI-SRA ( repository, accession number PRJNA1278808