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When AMPK is activated, cells increase glucose uptake independent of insulin, enhance fatty acid oxidation in mitochondria, and upregulate mitochondrial biogenesis

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The phagocytized non-photosynthetic bacteria (symbionts) over eons evolved into mitochondria while the engulfed photosynthesizing bacteria became chloroplasts (known as the well-established endosymbiotic theory) of the early eukaryotes and during this process the melatonin-synthesizing capacity of the bacteria-derived organelles, both chloroplasts and mitochondria, was retained ( Figure 2 )

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1 Despite the availability of multiple treatments, a substantial proportion of patients either fail to achieve remission, particularly in cases of treatment-resistant depression (TRD) and late-life depression