Some signs that you may need more fluids include: Dark yellow urine Going to the bathroom less often than usual Dry mouth Headache Dizziness or lightheadedness Feeling unusually tired or weak Muscle cramps Constipation Nausea that feels worse in the heat These symptoms can have different causes, and dehydration is not always the only explanation
10.1016/j.jgr.2019.09.003 244 YuanD.LiX.LuoC.LiX.ChengN.JiH.et al (2019)
People with Digestive Disorders: Conditions like Crohns disease, celiac disease, or those who have undergone weight loss surgery can impair the absorption of B12
This can lead to a feeling of puffiness, particularly in the hands, feet, and face
Binding mechanism: Unlike peptides that bind to both the ECD and TMD, small-molecule agonists primarily interact with an allosteric binding site within the TMD
This battle is called oxidative stress