When to Consult Your GP or Pharmacist You should contact your GP, prescribing clinician, or pharmacist before starting ispaghula if: You have difficulty swallowing or a history of oesophageal disorders You have a narrowing or obstruction anywhere in your gastrointestinal tract You experience severe or persistent constipation despite lifestyle measures You have diabetes requiring careful monitoring, as changes in fibre intake can affect blood glucose levels You take multiple medications, particularly those with narrow therapeutic windows or known interactions with fibre supplements You have kidney disease or are on a restricted diet, as some ispaghula formulations contain sodium or potassiumcheck the label or ask a pharmacist Seek urgent medical advice if you develop: Severe, persistent abdominal pain (with or without vomiting) which could suggest pancreatitis Right-upper-quadrant pain, fever or jaundice which might indicate gallbladder problems Difficulty swallowing or breathing after taking ispaghula Chest pain or vomiting Rectal bleeding or failure to have a bowel movement after using the product Signs of dehydration (dark urine, dizziness, reduced urination) Allergic reactions such as rash, itching, or facial swelling Regular review is important for anyone taking Wegovy, as dose adjustments and monitoring for side effects are part of safe prescribing practice

Results have not yet been reported
Far more important than the specific lipoplasty technique are the skill and expertise of the surgeon performing it
Significant weight loss has been observed with administration of the long acting GLP-1 receptor (GLP-1R) agonists liraglutide (1) and semaglutide (2), primarily by affecting satiety and food intake
The endoplasmic reticulum stress/unfolded protein response and their contributions to Parkinsons disease physiopathology
S., & Frech-Tamas, F