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It also has potential benefits in managing non-acetaminophen-induced acute liver failure by improving liver function and reducing oxidative damage

AMPK prevents palmitic acid-induced apoptosis and lipid accumulation in cardiomyocytes

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The qualifying diagnoses (HFpEF, uncontrolled hypertension, CKD, pre-diabetes, prior MI, prior stroke, PAD) are the conditions where GLP-1 trials have shown direct benefit or strong biological plausibility for benefit

In this case, Orforglipron can be a better option since it has no such restriction