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In 2023, the FDA and European Medicines Agency (EMA) began investigating a possible relationship after receiving reports of suicidal thoughts while patients were taking the drugs

Bifidobacterium infantis produces acetate and lactate, two metabolites that serve as fuel for both Akkermansia muciniphila and Clostridium butyricum

While 500mg is generally safe, very high doses may increase oxalate levels in some individuals

The SURMOUNT clinical trial program demonstrated weight loss results that shocked even the researchers running the studies, with participants on the highest dose losing an average of 22.5% of their body weight over 72 weeks

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