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In embryonic Drosophila , the activation of DUOX and subsequent H 2 O 2 production was shown to be triggered by wound-induced calcium (Ca 2+ ) flashes, where Ca 2+ binds to an EF hand Ca 2+ -binding motif of DUOX 72

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J Drug Target 15:475486 Gao F, Chen J, Ma T, Li H, Wang N, Li Z, Zhang Z, Zhou Y (2014) The glutathione peroxidase gene family in Thellungiella salsuginea: genome-wide identification, classification, and gene and protein expression analysis under stress conditions