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This beneficial effect is, at least in part, due to the activation of the MET-AKT/GSK-3 signaling pathway (Jia et al., 2020)

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Consistent with the transcriptomic findings, proteomic analysis of liver from Gclc KO mice revealed that most significantly elevated proteins in Gclc KO liver were encoded by NRF2 target genes, including the canonical NRF2 target NQO1 (NAD(P)H Quinone Dehydrogenase 1) (Fig