is retatrutide approved 2025 vs Ozempic: Clinical Trial Comparisons The Retatrutide Dosage Chart

But what exactly does that stand for

It means one-day adjustments become even less consequential over time

In a Phase 2 randomised controlled trial published in the New England Journal of Medicine in 2023 (Jastreboff et al., NEJM 2023), adults with obesity (without type 2 diabetes) who received the highest dose of retatrutide (12 mg weekly) achieved a mean body weight reduction of approximately 24% over 48 weeks

For those with more skin laxity, two sessions are recommended

Another study published by Diabetes, Obesity & Metabolism in June 2025 further supported this link, concluding that the five-year risk of developing NAION doubled in patients using GLP-1 drugs compared to non-users

If you miss a dose of retatrutide whilst participating in a clinical trial, you should follow the specific missed-dose instructions provided by your trial team rather than general guidance, as protocols vary between trials