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Adipose lipolysis is important for ethanol to induce fatty liver in the National Institute on Alcohol Abuse and Alcoholism murine model of chronic and binge ethanol feeding

It functions like an organ by releasing hormones and inflammatory markers

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Identified CoUs include biomarkers of risk (e.g., APOE4 ), diagnosis (e.g., amyloid PET, CSF AD biomarkers), monitoring (e.g., blood-based biomarkers of p-tau and NfL), pharmacodynamic response (e.g., amyloid PET, tau PET), prognosis (p-tau, Up53), treatment response prediction (none known for predicting benefit

15 In mammals, this process is catalyzed by enzymes encoded by genes such as CntA/B, CutC, and betaine reductase