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Once senescent cells are removed, the downstream benefits continue to develop as: SASP-driven inflammation progressively resolves Stem cell niches, previously suppressed by SASP factors, may reactivate Tissue remodeling and repair processes engage in cleared areas The paracrine senescence cascade (where SASP converts healthy cells to senescent ones) is interrupted In mouse models, improvements in kidney function and physical fitness persisted and in some cases continued to develop during the weeks following treatment cessation (Baar et al., 2017)

doi: 10.1007/s11033-025-10261-4 76 ZhaoCWuSWangH

Initiation of treatment in patients with NYHA Class III or IV heart failure is CONTRAINDICATED

Trong qu trnh gii c methylglyoxal, mt sn phm ph c hi ca trao i cht, L-glutathione c glyoxalase I chuyn i thnh S-D-Lactoyl-glutathione v sau glyoxalase II chuyn i thnh glutathione kh v D-lactate

n = 1367 cells, 4 mice) or Glp1r-ires-crexGnas fl/fl mouse (KO