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Everolimus, an mTOR signaling pathway inhibitor typically used in tumor-targeted therapy, inhibits the mTOR3EBP4 axis, reduces GPX4 expression, and acts synergistically with RSL3 or erastin to induce ccRCC cell ferroptosis (145)

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Instead, these organs employ an amino acid transporter to absorb glycine, cysteine, and glutamate for intracellular de novo GSH synthesis

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