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Some neurological symptoms may continue improving for up to 1218 months, though permanent damage can occur if deficiency was severe and prolonged

Early research suggests that MOTS-C peptide may influence pathways such as AMPK activation and antioxidant gene expression, hinting at potential roles in metabolic health, physical performance, and age-related decline

Lancet 373(9669):10971104 Druker BJ et al (2006) Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia

I suspect the absolute risk is low for short-term use, but we do not actually know, and that uncertainty alone is a strong argument against chronic use

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