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Eli Lilly developed the peptide as the next step beyond dual incretin agonists such as tirzepatide, and researchers now study it across obesity, type 2 diabetes and metabolic liver disease

Safety and Tolerability Both compounds share a dominant, mostly mild-to-moderate gastrointestinal adverse-event profile nausea, vomiting, diarrhea, constipation, abdominal pain concentrated during dose escalation

doi: 10.1002/prp2.825 146 AryanHFarahaniRHChamanaraMElyasiSJaafariMRHaddadMet al

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