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According to meta-analysis data, hypothyroidism occurs in about 3.8% of patients treated with anti-CTLA-4, 3.9% with anti-PD-L1, 7.0% with anti-PD-1, and 13.2% with combination therapy

10.1111/j.1749-6632.1999.tb08645.x 42 Le PrellC

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Researchers have safely applied these doses for up to two weeks based on the available case reports [6, 8, 14]

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