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This is one of the few head-to-head trials in this drug class, and it showed mazdutide outperforming semaglutide 1 mg on both glycemic control and weight loss

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It works by activating GLP-1 receptors that help regulate appetite, blood sugar levels, and feelings of fullness after eating

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Whether semaglutide specifically confers the same benefits is less well established, and any similar or enhanced indirect effects from retatrutide remain speculative in the absence of dedicated study data